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Cover Focus | May 2021

Yamane Tips and Tricks

Advice from a panel of surgeons.

A Dozen Pearls

Zaina Al-Mohtaseb, MD

The double-needle, small-incision, sutureless, transconjunctival scleral fixation technique was first described by Yamane et al in 2017.1 It uses small-gauge sclerotomies and a small clear corneal incision. The Yamane technique is associated with a quick visual recovery and a low risk of postoperative hypotony. Neither capsular nor iris support is required, and suture-related complications are avoided.

It is important to note, however, that only short-term data on the safety and efficacy of this technique are available. Moreover, because this is a two-point fixation technique, there is a risk of IOL decentration and tilt, and great precision is required to decrease this risk (watch a related video below). Additionally, the learning curve is steep.

TWELVE TIPS

My contribution in this article contains 12 tips and tricks to help with mastering this technique.

No. 1: Use the TSK thin-walled special 30-gauge needles. Make sure to loosely attach the needles to a non–luer-locking tuberculin syringe filled with balanced salt solution. This fill prevents bubbles from entering at the tip of the needle, which can make threading the haptic difficult.

No. 2: Implant the most appropriate IOL. The CT Lucia 602 (Carl Zeiss Meditec) is the ideal three-piece lens to use for the Yamane technique because its PVDF haptics resist kinking and breakage.

No. 3: Keep an eye on the pressure. An anterior chamber maintainer or an infusion cannula is vital to maintaining IOP and ensuring that both sclerotomy passes are similar in length and location.

No.4: Check for adequate support. If iris support is inadequate and the IOL is in danger of being lost posteriorly during the procedure, a small amount of a miotic agent injected intracamerally will constrict the pupil slightly. This helps create a platform on which to rest the leading haptic. I like leaving the trailing haptic of the three-piece lens outside the wound.

No. 5: Prevent postoperative tilt and decentration of the IOL. The needles must be inserted exactly 180º apart and 2.5 mm posterior to the limbus unless the axial length of the eye is extremely short or long. Also, the sclerotomy tunnels must be equal in length.

No. 6: Be prepared for chemosis and subconjuctival hemorrhage. If chemosis or a subconjunctival hemorrhage develops, especially in combination cases, it is best to perform a limited peritomy to ensure that the sclerotomy passes are performed correctly.

No. 7: Stabilize the globe. A good tip is to place toothed forceps near the marked point of needle insertion during the scleral insertion.

No. 8: Thread the trailing haptic with care. The most technically difficult step of the Yamane technique is threading the trailing haptic into the needle. I recommend creating a paracentesis approximately 180º away from the sclerotomy to optimize the direction of the intraocular 25-gauge Grieshaber Maxgrip forceps (Alcon) so that the haptic can be grasped parallel to its span and more in line with the 30-gauge needle. Alternatively, the wound may be created slightly to the left of the 180º meridian.

No. 9: Look for proper centration of the IOL. Slowly remove both needles simultaneously and observe the optic’s centration. It is important to look for decentration and tilt before cauterizing the haptics.

No. 10: Recenter the IOL if necessary. If IOL centration is poor or the IOL is tilted and the needle insertions are not 180º apart or not located the same distance from the limbus, then one of the haptics must be reinserted into the eye and refixated with a new needle pass. If IOL centration is poor because the scleral tunnels differ in length, one or both haptics can be trimmed and then cauterized to improve centration.

No. 11: Avoid pupillary capture of the iris. Insert the needle 2.5 mm instead of 2 mm posterior to the limbus. Alternatively, a peripheral iridotomy may be performed.

No. 12: Target slight myopia. Choose a refractive target of -0.50 to -0.75 D to avoid a postoperative hyperopic surprise.2

1. Yamane S, Sato S, Maruyama-Inoue M, Kadonosono K. Flanged intrascleral intraocular lens fixation with double-needle technique. Ophthalmology. 2017;124(8):1136-1142.

2. McMillin J, Wang L, Wang MY, et al. Accuracy of intraocular lens calculation formulas for flanged intrascleral intraocular lens fixation with double-needle technique. J Cataract Refract Surg. Published online December 9, 2020. doi:10.1097/j.jcrs.0000000000000540


Major Difficulties and How to Address Them

Nicole R. Fram, MD

I have been using the Yamane technique since 2017, when Shin Yamane, MD, PhD, first published his results.1 Before that, I had been using various scleral and iris fixation techniques. These are the seven most important lessons I have learned over the past 3.5 years.

LESSONS LEARNED

No. 1: Perform an adequate vitrectomy. A vitrectomy is required before any scleral fixation technique is performed. At the outset of every case, I look for vitreous prolapse by injecting preservative-free triamcinolone acetonide to stain vitreous strands. I then inject an OVD and perform a pars plana–assisted anterior vitrectomy through preplaced 23- or 25-gauge trocars depending on the vitrectomy unit.

No. 2: Know where to make the main incision. The Baylor group taught me to make my main 3-mm clear corneal temporal incision a little bit supratemporal to 180º for the right eye (infratemporal for the left eye) so that the proximal haptic docks more easily. Additionally, leaving the trailing (proximal) haptic outside of the incision before the scleral tunnel needle pass can assist with a parallel docking.

No. 3: Avoid tilt. The IOL can tilt if there is an asymmetry in needle entry points or tunnel length. The entry points should be exactly 180º apart and at least 2 mm back from the limbus depending on the white-to-white measurement. Each scleral tunnel has to be symmetrical and measure 1.5 to 2 mm in length. This can be a challenge if conjunctival chalasis or chemosis is present. If this is the case, the conjunctiva must be taken down to confirm symmetry of entry and tunnel length. Angulation is another major consideration: The needles should enter at a 20º angle to the limbus in order to approximate the natural curvature of the haptics and avoid tilt, as Dr. Yamane described in his original technique.1

No. 4: Avoid pupillary capture of the optic. The reason for pupillary capture involves inherent iridodonesis in vitrectomized eyes and asymmetric entry of the needles into the eye. A laser peripheral iridotomy may be used to treat uveitis-glaucoma-hyphema syndrome in eyes with reverse pupillary block that receive sulcus-fixated IOLs.2 This concept is applicable to the Yamane technique provided that IOL tilt is not severe.

I typically perform peripheral iridotomies on all patients with scleral fixation by using the vitrector on I/A settings with a vacuum level of 700 mm Hg and a cut rate of 100 cuts per minute. If there is excessive iridodonesis, I perform two surgical peripheral iridotomies 90º apart. If the eye has pupillary capture, I use ultrasound biomicroscopy (Figures 1 and 2) to distinguish between excessive iridodonesis without adequate peripheral iridotomies to equilibrate the anterior and posterior chambers (Figure 1) and significant IOL tilt (Figure 2). This distinction is important because leaving an excessively tilted IOL in these eyes can cause chronic pigment dispersion, iris transillumination defects, and potentially chronic cystoid macular edema or ocular inflammation.

Figure 1. Ultrasound biomicroscopy revealing excellent IOL placement without tilt and a draping of the iris over the edge of the IOL. The treatment was two surgical peripheral iridotomies.

Figure 2. Ultrasound biomicroscopy of a tilted IOL after intrascleral haptic fixation (Yamane technique) causing significant tilt, uveitis-glaucoma-hyphema syndrome, and iris chafing with transillumination defects.

Figures 1 and 2 courtesy of Nicole R. Fram, MD

For example, in the eyes I have treated for pupillary capture and tilt, the needle entry into the eye from the limbus was approximately 1.8 mm on one side and 1.5 mm from the limbus on the captured side. The more anterior haptic entry was retrieved, cut on a bevel, tested outside the eye for ability to dock into a thin-walled 30-gauge needle, and then brought into the eye for redocking more posteriorly. This resolved the issue.

No. 5: Bury the terminal bulb. An unburied flange can cause conjunctival erosion and create a nidus for infection, scleritis, and endophthalmitis. The flanges on various types of haptics can differ; PVDF haptics create a mushroom bulb, and PMMA haptics create a triangular flange.

At the end of every case, I make a little buttonhole on the conjunctiva or Tenon capsule, and I look at the terminal haptic bulb. I then grab the sclera and push the terminal bulb into the scleral tunnel with one end of a straight forceps. I do not want the terminal bulb to sit under the conjunctiva. In some of my early cases, I thought I had pushed the bulb all the way in when it was actually wrapped around Tenon capsule and pulled out as it healed. The terminal bulb of the haptic was slightly extruded under the conjunctiva, which is not ideal in eyes with thin conjunctiva.

No. 6: Do a final check. It is not sufficient to insert the lens optic and hope for the best. Centration of the IOL must be verified at the end of the case, and the only way to do this is to use iris hooks and look.

No. 7: Choose the right tools. The CT Lucia 602 IOL is my preferred IOL because its PVDF haptics facilitate burial of the bulb. Unfortunately, availability of this IOL has been limited. My preferred alternative is the Tecnis IOL (model ZA9003, Johnson & Johnson Vision). Its PMMA haptics may bend, so it is important to understand the importance of angles and how to dock the needles.

The proper needles for the Yamane technique have thin walls. The needles included in the Scleral IOL Fixation Solutions Pack (MicroSurgical Technology) are excellent choices for this technique as are the TSK thin-walled 30-gauge needles.

1. Yamane S, Sato S, Maruyama-Inoue M, Kadonosono K. Flanged intrascleral intraocular lens fixation with double-needle technique. Ophthalmology. 2017;124(8):1136-1142.

2. Singh H, Modabber M, Safran SG, Ahmed II. Laser iridotomy to treat uveitis-glaucoma-hyphema syndrome secondary to reverse pupillary block in sulcus-placed intraocular lenses: case series. J Cataract Refract Surg. 2015;41(10):2215-2223.

Zaina Al-Mohtaseb, MD
  • Associate Professor of Ophthalmology and Associate Residency Program Director, Cornea, Cataract & Refractive Surgery, Cullen Eye Institute, Department of Ophthalmology, Baylor College of Medicine, Houston
  • Member, CRST Executive Advisory Board
  • zaina@bcm.edu; Twitter @Zaina_1225
  • Financial disclosure: Consultant (Alcon, Carl Zeiss Meditec)
Nicole R. Fram, MD
  • Private practice, Advanced Vision Care, Los Angeles
  • Clinical Instructor of Ophthalmology, Jules Stein Eye Institute, University of California, Los Angeles
  • Member, CRST Editorial Advisory Board
  • nicfram@yahoo.com
  • Financial disclosure: Consultant (Alcon, Allergan, Carl Zeiss Meditec, CorneaGen, Johnson & Johnson Vision); Equity owner (CorneaGen, Ocular Science); Lecture fees (Alcon, Bausch + Lomb, Johnson & Johnson Vision)

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